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The FDA provided orphan medicine designation for fixed-dose combination of tesofensine and metoprolol in PWS in March 2021 and hypothalamic weight problems in July 2021. Tesofensine is a centrally acting monoamine reupt Visit Ep3509597a1 Tesofensine Compositions (https://s3.us-east-1.amazonaws.com/pharma-regulations/clinical-trials/product-lifecycle/ep3509597a1-tesofensine.html)
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